Myocardial cell sheet therapy and cardiac function
نویسندگان
چکیده
منابع مشابه
Myocardial cell sheet therapy and cardiac function.
Heart failure (HF) is the leading cause of death in developed countries. Regenerative medicine has the potential to drastically improve treatment for advanced HF. Stem cell-based medicine has received attention as a promising candidate therapy over the past decade; however, it has not yet realized this potential in terms of reliability. The cell sheet is an innovative technology for constructin...
متن کاملSmooth muscle cell sheet transplantation preserve cardiac function and minimize cardiac remodeling in a rat myocardial infarction model
BACKGROUND We examined whether a vascular smooth muscle cell (SMC) sheet is effective in the treatment of a rat myocardial infarction (MI) model. METHODS We examined the effect of SMC sheet on the cardiac function and cardiac remodeling in a rat MI model in comparison with their effect of dermal fibroblast (DFB) sheet in vivo. Furthermore, we estimated the apoptosis and secretion of angiogeni...
متن کامل[Translational research of cell sheet-based myocardial regeneration therapy].
幹 細 胞 研 究 と 臨 床 利 用 の 進 歩 3 要約:重症心不全治療として最も重要な治療法である 心臓移植は,極めて深刻なドナー不足であり,新しい 移植法案が可決されたものの,欧米レベルの汎用性の 高い治療法としての普及は困難が予想される.一方, 左室補助人工心臓(LVAD)については,日本では移植 待機期間が長期であるため,感染症や脳血栓等の合併 症が成績に大きく影響している.このような状況を克 服するため,世界的に再生医療への期待が高まってい るが,重症心不全を治癒させるまでに至らず,心臓移 植や LVADに代わる新しい治療開発が急務である.こ のような現状のなか,重症心不全においては,細胞移 植,組織移植,また再生医療的手法を用いた再生創薬 の研究がすすみ,臨床応用化が進んでいる.本稿では, これまでの筋芽細胞シートのトランスレーショナルリ サーチとともに,iPS細胞由...
متن کاملCortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction.
RATIONALE Cortical bone stem cells (CBSCs) have been shown to reduce ventricular remodeling and improve cardiac function in a murine myocardial infarction (MI) model. These effects were superior to other stem cell types that have been used in recent early-stage clinical trials. However, CBSC efficacy has not been tested in a preclinical large animal model using approaches that could be applied ...
متن کاملSca-1 knockout impairs myocardial and cardiac progenitor cell function.
RATIONALE Cardiac progenitor cells are important for maintenance of myocardial structure and function, but molecular mechanisms governing these progenitor cells remain obscure and require elucidation to enhance regenerative therapeutic approaches. OBJECTIVE To understand consequences of stem cell antigen-1 (Sca-1) deletion on functional properties of c-kit+ cardiac progenitor cells and myocar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2012
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00376.2012